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Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-29 , DOI: 10.1039/d0tb00544d Halston E Deal 1 , Ashley C Brown 1 , Michael A Daniele 2
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-29 , DOI: 10.1039/d0tb00544d Halston E Deal 1 , Ashley C Brown 1 , Michael A Daniele 2
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Wound healing is a multivariate process involving the coordinated response of numerous proteins and cell types. Accordingly, biomedical research has seen an increased adoption of the use of in vitro wound healing assays with complexity beyond that offered by traditional well-plate constructs. These microphysiological systems (MPS) seek to recapitulate one or more physiological features of the in vivo microenvironment, while retaining the analytical capacity of more reductionist assays. Design efforts to achieve relevant wound healing physiology include the use of dynamic perfusion over static culture, the incorporation of multiple cell types, the arrangement of cells in three dimensions, the addition of biomechanically and biochemically relevant hydrogels, and combinations thereof. This review provides a brief overview of the wound healing process and in vivo assays, and we critically review the current state of MPS and supporting technologies for modelling and studying wound healing. We distinguish between MPS that seek to inform a particular phase of wound healing, and constructs that have the potential to inform multiple phases of wound healing. This distinction is a product of whether analysis of a particular process is prioritized, or a particular physiology is prioritized, during design. Material selection is emphasized throughout, and relevant fabrication techniques discussed.
中文翻译：
用于伤口愈合建模和促愈合疗法评估的微生理学系统。
伤口愈合是一个多变量过程，涉及多种蛋白质和细胞类型的协调反应。因此，生物医学研究越来越多地采用体外伤口愈合测定，其复杂性超出了传统孔板结构所提供的范围。这些微生理系统（MPS）寻求概括体内微环境的一种或多种生理特征，同时保留更多还原性测定的分析能力。实现相关伤口愈合生理学的设计工作包括在静态培养上使用动态灌注、合并多种细胞类型、细胞在三个维度上的排列、添加生物力学和生物化学相关的水凝胶及其组合。这篇综述简要概述了伤口愈合过程和体内测定，我们批判性地回顾了 MPS 的现状以及用于建模和研究伤口愈合的支持技术。我们区分了试图告知伤口愈合特定阶段的 MPS 和有可能告知伤口愈合多个阶段的结构。这种区别是设计过程中是否优先考虑特定过程的分析或优先考虑特定生理学的产物。全文强调了材料的选择，并讨论了相关的制造技术。
更新日期：2020-08-19
中文翻译：
用于伤口愈合建模和促愈合疗法评估的微生理学系统。
伤口愈合是一个多变量过程，涉及多种蛋白质和细胞类型的协调反应。因此，生物医学研究越来越多地采用体外伤口愈合测定，其复杂性超出了传统孔板结构所提供的范围。这些微生理系统（MPS）寻求概括体内微环境的一种或多种生理特征，同时保留更多还原性测定的分析能力。实现相关伤口愈合生理学的设计工作包括在静态培养上使用动态灌注、合并多种细胞类型、细胞在三个维度上的排列、添加生物力学和生物化学相关的水凝胶及其组合。这篇综述简要概述了伤口愈合过程和体内测定，我们批判性地回顾了 MPS 的现状以及用于建模和研究伤口愈合的支持技术。我们区分了试图告知伤口愈合特定阶段的 MPS 和有可能告知伤口愈合多个阶段的结构。这种区别是设计过程中是否优先考虑特定过程的分析或优先考虑特定生理学的产物。全文强调了材料的选择，并讨论了相关的制造技术。
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