We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

中文翻译：

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发现针对金黄色葡萄球菌受体组氨酸激酶 AgrC 的膜嵌入传感器域的群体淬灭剂。

我们将 mRNA 展示技术与基于脂质纳米盘的选择相结合，并确定了靶向组氨酸激酶 AgrC 的完整膜传感器域的高亲和力配体作为金黄色葡萄球菌群体感应调节毒力的有效抑制剂。我们的研究强调了这种整合方法在鉴定整合膜蛋白的功能调节剂方面的潜力。