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In vitro and in vivo studies on ultrafine-grained biodegradable pure Mg, Mg-Ca alloy and Mg-Sr alloy processed by high-pressure torsion.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-07-29 , DOI: 10.1039/d0bm00805b
Wenting Li 1 , Xiao Liu , Yufeng Zheng , Wenhao Wang , Wei Qiao , Kelvin W K Yeung , Kenneth M C Cheung , Shaokang Guan , Olga B Kulyasova , R Z Valiev
Affiliation  

High-pressure torsion (HPT) can refine the microstructure and consequently modify the properties, such as mechanical and corrosion properties, of Mg and its alloys. Biodegradable magnesium materials alloyed with the essential elements of life, such as Ca and Sr, are a current research frontier. In this study, biodegradable ultrafine-grained pure Mg, Mg–Ca alloy, and Mg–Sr alloy were prepared using HPT processing. The microstructure, mechanical properties, biodegradable behaviors, and biocompatibility in vitro and in vivo of these materials were systematically investigated. Our results revealed that HPT pure Mg with a bimodal and ultrafine-grained microstructure showed higher mechanical strength, ductility, and degradation rate compared with the as-received materials. The good biocompatibility of HPT pure Mg was confirmed both in vitro and in vivo. The HPT Mg–Ca alloy and Mg–Sr alloy with homogeneous ultrafine-grained microstructures showed higher mechanical strength and lower degradation rate than their as-cast counterparts. The good biocompatibility of the HPT Mg–Ca alloy and Mg–Sr alloy was also revealed. All these findings indicate that HPT is an alternative avenue to fabricate biodegradable Mg-based materials.

中文翻译:

高压扭转加工超细颗粒可生物降解的纯Mg,Mg-Ca合金和Mg-Sr合金的体内和体外研究。

高压扭转(HPT)可以改善微观结构,从而改变Mg及其合金的性能,例如机械性能和腐蚀性能。与生命的基本元素(例如Ca和Sr)合金化的可生物降解的镁材料是当前的研究前沿。在这项研究中,使用HPT工艺制备了可生物降解的超细颗粒纯Mg,Mg-Ca合金和Mg-Sr合金。体外体内的微观结构,力学性能,可生物降解的行为和生物相容性对这些材料中的一部分进行了系统的研究。我们的结果表明,与原态材料相比,具有双峰和超细晶粒组织的HPT纯Mg具有更高的机械强度,延展性和降解速率。HPT纯Mg的良好的生物相容性都被证实在体外体内。具有均质超细晶粒组织的HPT Mg-Ca合金和Mg-Sr合金比铸态合金具有更高的机械强度和更低的降解率。还显示了HPT Mg-Ca合金和Mg-Sr合金的良好生物相容性。所有这些发现表明,HPT是制造可生物降解的镁基材料的替代途径。
更新日期:2020-09-15
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