The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients. In this Comment article, Becker and colleagues consider how the excessive release of reactive oxygen species by neutrophils may perpetuate red blood cell dysfunction, thrombosis and tissue damage in severe cases of COVID-19.

中文翻译：

---

中性粒细胞诱导的氧化应激在COVID-19中对组织的损害。

在重症COVID-19患者中观察到的高嗜中性粒细胞与淋巴细胞比例与过量的活性氧（ROS）有关，活性氧促进了一系列生物学事件，从而推动病理宿主反应。ROS引起组织损伤，血栓形成和红细胞功能障碍，从而加剧了COVID-19疾病的严重性。我们建议自由基清除剂可能对最脆弱的患者有益。在这篇评论文章中，贝克尔及其同事考虑了在严重的COVID-19病例中，嗜中性粒细胞过度释放活性氧可能如何使红细胞功能障碍，血栓形成和组织损伤永存。