Abstract

In this work, a series of oxidized starch-based bio-nanocomposites (OS/CuO) were prepared and investigated as colon drug delivery vehicles. The appearance of peaks at 400–800 cm⁻¹ of FTIR spectrum, as well as, peaks at 2θ 35°, 39°, and 49° of XRD spectrum could be a good sign for successful synthesis of the CuO within hydrogel network. The effect of Cu²⁺ concentration on swelling, NPX loading, and release behavior was examined and the highest value obtained for the C2 sample. Moreover, C4 displayed the highest antibacterial activity. Obtained results indicated that the prepared systems are suitable for use in medical applications.

摘要

在这项工作中，制备并研究了一系列氧化淀粉基生物纳米复合材料 (OS/CuO) 作为结肠药物递送载体。在FTIR 光谱的400–800 cm ^-1处出现峰，以及在XRD 光谱的2 θ 35°、39° 和 49° 处出现峰可能是在水凝胶网络中成功合成 CuO 的好兆头。检查了 Cu ²⁺浓度对溶胀、NPX 负载和释放行为的影响，并获得了 C2 样品的最高值。此外，C4 显示出最高的抗菌活性。获得的结果表明所制备的系统适用于医疗应用。