ABSTRACT Rheumatoid arthritis (RA) is characterised by the infiltration of a number of proinflammatory cytokines into synovial fluid. Soya-cerebroside, an extract from Cordyceps militaris, inhibits synovial inflammation and reduces cartilage damage in an osteoarthritis model, although the role of soya-cerebroside in inflammatory cytokine expression in RA is uncertain. In this study, Gene Expression Omnibus (GEO) database records revealed higher levels of interleukin (IL)-1β, IL-6 and IL-8 in RA tissue compared with normal tissue. Elevated levels of these inflammatory cytokines were also higher in mice with collagen-induced arthritis (CIA) than in control mice. Soya-cerebroside effectively inhibited IL-1β, IL-6 and IL-8 expression in RA synovial fibroblasts, apparently by inhibiting the ERK, NF-κB and AP-1 signalling pathways. This anti-inflammatory agent shows promise for the treatment of RA.

中文翻译：

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大豆脑苷脂通过抑制 ERK、NF-κB 和 AP-1 信号通路减少人类风湿性关节炎滑膜成纤维细胞中白细胞介素的产生

摘要 类风湿性关节炎 (RA) 的特征是许多促炎细胞因子浸润到滑液中。大豆脑苷脂是一种来自蛹虫草的提取物，在骨关节炎模型中抑制滑膜炎症并减少软骨损伤，尽管大豆脑苷脂在 RA 中炎症细胞因子表达中的作用尚不确定。在这项研究中，基因表达综合 (GEO) 数据库记录显示，与正常组织相比，RA 组织中的白细胞介素 (IL)-1β、IL-6 和 IL-8 水平更高。胶原诱导性关节炎 (CIA) 小鼠中这些炎性细胞因子的升高水平也高于对照组小鼠。大豆脑苷脂有效抑制 RA 滑膜成纤维细胞中 IL-1β、IL-6 和 IL-8 的表达，显然是通过抑制 ERK、NF-κB 和 AP-1 信号通路。