Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.

中文翻译：

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人巨细胞病毒感染中钙和AMPK信号之间的相互作用。

钙信号和AMP激活的蛋白激酶（AMPK）信号网络广泛调节细胞生物学的许多方面。已发现人类巨细胞病毒（HCMV）感染可主动操纵钙-AMPK信号轴来支持感染。许多HCMV基因与调节钙信号有关，并且发现HCMV感染依赖于钙信号和AMPK激活。在这里，我们专注于钙和AMPK信号传导的细胞生物学，以及目前关于HCMV如何调节这些途径以支持HCMV感染并可能促成调制的知识。