Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.

中文翻译：

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含吲哚菁绿的可附着水凝胶，用于针对黑素瘤的选择性光热疗法。

黑色素瘤是最致命的皮肤癌形式，因为它容易扩散到其他组织，从而降低了通过化学疗法，放射疗法和外科疗法的治疗效率。我们建议将可附着的水凝胶用于黑色素瘤的治疗，从而可以控制用于光热疗法（PTT）的吲哚菁绿（ICG）的大小和数量。使用生物相容性聚合物制造了将ICG用作近红外（NIR）吸收剂的可附着水凝胶（聚（丙烯酰胺-共二烯丙基二甲基氯化铵）； PAD）。在808 nm激光照射下，PAD-ICG的温度升高。水凝胶可保护ICG免受分解；因此，PAD-ICG可以重新用于PTT。使用NIR激光照射，将PAD-ICG附着在小鼠黑色素瘤区域，成功消除了黑色素瘤。因此，数据表明PAD-ICG是一种智能材料，可用于针对人类黑色素瘤的选择性靶标治疗。