Abstract

Heterocycles are ubiquitous structures in nature and can be found in many drugs and chemicals. Biocatalysts, alone or in combination with other metal catalysts, can be exploited for the construction of various heterocyclic rings under mild reaction conditions. This Short Review highlights the recent advances in the development of biocatalytic and chemo-enzymatic methods for the synthesis of both aliphatic and aromatic heterocyclic rings.

1 Introduction

2 Synthesis of Aliphatic Heterocycles

2.1 Piperidines, Pyrrolidines and Piperazines

2.2 Other Nitrogen-Containing Aliphatic Heterocycles

2.3 Lactones and Lactams

2.4 Other Oxygen-Containing Heterocycles

3 Synthesis of Aromatic Heterocycles

3.1 Pyrroles, Pyridines and Pyrazines

3.2 Furans

3.3 Bicyclic Aromatic Heterocycles

4 Conclusion

中文翻译：

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杂环合成的生物催化和化学酶促方法

摘要

杂环是自然界中普遍存在的结构，可以在许多药物和化学药品中找到。可以单独使用或与其他金属催化剂组合使用生物催化剂，以在温和的反应条件下构建各种杂环。这篇简短的综述着重介绍了用于脂肪族和芳香族杂环合成的生物催化和化学酶方法的最新进展。

1引言

2脂肪族杂环的合成

2.1哌啶，吡咯烷和哌嗪

2.2其他含氮脂肪族杂环

2.3内酯和内酰胺

2.4其他含氧杂环

3芳香杂环的合成

3.1吡咯，吡啶和吡嗪

3.2呋喃

3.3双环芳香杂环

4。结论