It has been more than a decade since the last comprehensive review of the phase-variable uropathogen-associated pyelonephritis-associated pilus (pap) genetic switch. Since then, important data have come to light, including additional factors that regulate pap expression, better characterization of H-NS regulation, the structure of the Lrp octamer in complex with pap regulatory DNA, the temperature-insensitive phenotype of a mutant lacking the acetyltransferase RimJ, evidence that key components of the regulatory machinery are acetylated, and new insights into the role of DNA binding by key regulators in shaping both the physical structure and regulatory state of the papI and papBA promoters. This review revisits pap, integrating these newer observations with older ones to produce a new model for the concerted behavior of this virulence-regulatory region.

中文翻译：

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热敏、相变表观遗传开关：重新审视 pap。


自上次对相变尿路病原体相关肾盂肾炎相关菌毛（ pap ）基因开关进行全面审查以来，已经过去十多年了。从那时起，重要的数据逐渐浮出水面，包括调节pap表达的其他因素、H-NS 调节的更好表征、与pap调节 DNA 复合的 Lrp 八聚体的结构、缺乏乙酰转移酶的突变体的温度不敏感表型RimJ，证明调节机制的关键组件被乙酰化的证据，以及对关键调节因子 DNA 结合在塑造papI和papBA启动子的物理结构和调节状态中的作用的新见解。这篇综述重新审视了pap ，将这些新的观察结果与旧的观察结果相结合，为这个毒力调节区域的协调行为产生一个新模型。