NUP98‐HOXA10hd fusion protein sustains multi‐lineage haematopoiesis of lineage‐committed progenitors in transplant setting,Cell Proliferation

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NUP98‐HOXA10hd fusion protein sustains multi‐lineage haematopoiesis of lineage‐committed progenitors in transplant setting
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-07-29 , DOI: 10.1111/cpr.12885
Yong Dong _{1,

2,

3,

4} , Kaitao Wang ₁ , Qitong Weng _{1,

2,

3} , Tongjie Wang _{1,

2} , Peiqing Zhou _{1,

2,

3} , Xiaofei Liu _{1,

2} , Yang Geng _{1,

2} , Lijuan Liu _{1,

2} , Hongling Wu _{1,

2} , Jinyong Wang _{1,

2,

3,

5,

6} , Juan Du _{1,

2,

3,

5,

6}

Affiliation

Exploring approaches of extending the haematopoiesis time window of MPPs and lineage‐committed progenitors might produce promising therapeutic effects. NUP98‐HOXA10hd (NA) fusion protein can expand long‐term haematopoietic stem cells (HSCs) and promote engraftment competitiveness without causing obvious oncogenesis. Our objectives were to investigate the roles of NA fusion protein in MPP and downstream lineage‐committed progenitor context.

中文翻译：

NUP98-HOXA10hd融合蛋白维持移植环境中谱系定向祖细胞的多谱系造血

探索延长 MPP 和谱系承诺祖细胞的造血时间窗口的方法可能会产生有希望的治疗效果。NUP98-HOXA10hd（NA）融合蛋白可以扩大长期造血干细胞（HSC）并促进植入竞争力，而不会引起明显的肿瘤发生。我们的目标是研究 NA 融合蛋白在 MPP 和下游谱系定向祖细胞环境中的作用。

更新日期：2020-07-29

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