Synthesis of α‐Aminocyclopropyl Ketones and 2‐Substituted Benzoimidazoles from 2‐Hydroxycyclobutanones and Aryl Amines,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of α‐Aminocyclopropyl Ketones and 2‐Substituted Benzoimidazoles from 2‐Hydroxycyclobutanones and Aryl Amines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-07-28 , DOI: 10.1002/adsc.202000541
Lorenzo Serusi ₁ , Francesco Soddu ₁ , Federico Cuccu ₁ , Giuseppe Peretti ₁ , Alberto Luridiana ₁ , Francesco Secci ₁ , Pierluigi Caboni ₂ , David J. Aitken ₃ , Angelo Frongia ₁

Affiliation

We have developed one‐step protocols for the preparation of a large selection of α‐aminocyclopropyl ketones or benzo[d]imidazoles, by reacting 2‐substituted‐2‐hydroxycyclobutanones with aryl amines or o‐phenylenediamines, respectively. In most case the reactions proceed at room temperature and are catalyst‐free. The formation of benzo[d]imidazoles is rationalized in terms of an unusual ring‐closure/ring‐fission process followed by aromatization.

中文翻译：

由2-羟基环丁酮和芳胺合成α-氨基环丙基酮和2-取代的苯并咪唑

我们已经开发出了一步法，可以通过使2-取代-2-羟基环丁酮分别与芳基胺或邻苯二胺反应来制备大量的α-氨基环丙基酮或苯并[d]咪唑。在大多数情况下，反应在室温下进行且无催化剂。苯并[d]咪唑的形成应通过不寻常的闭环/裂变过程然后进行芳构化来合理化。

更新日期：2020-10-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11