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Induction of diverse T cell memory through antibody-mediated activation in mice.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-06 , DOI: 10.1002/eji.202048570
Matthew D Taylor 1 , Mariana R Brewer 1 , Clifford S Deutschman 1
Affiliation  

Recent studies have demonstrated that laboratory mice lack a robust repertoire of memory T cell. Administration of an anti‐CD3ε activating antibody (clone 145‐2C11) induces persistent CD4 and CD8 T cell memory in both lymphatic and solid organs while maintaining T cell responses and without increased anergy or altering innate immunity.
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中文翻译:

通过抗体介导的小鼠激活诱导不同的 T 细胞记忆。

最近的研究表明,实验室小鼠缺乏强大的记忆 T 细胞库。施用抗 CD3ε 激活抗体(克隆 145-2C11)可在淋巴和实体器官中诱导持久的 CD4 和 CD8 T 细胞记忆,同时维持 T 细胞反应,且不会增加无反应性或改变先天免疫。
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更新日期:2020-07-06
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