This study investigated the effect of Astaxanthin (ASTX) on levels and activities of the clotting factors in control rats. Untreated or ASTX‐treated rats (10 mg/kg, dissolved in DMSO) were used in this study. ASTX treatment was conducted for 10 days daily. ASTX significantly decreased the platelet count and prolonged values of prothrombin and activated partial thromboplastin time (PT and aPTT, respectively). Besides, it significantly reduced serum levels of vitamin K and the plasma activities and hepatic expression of vitamin K‐dependent factors (FII, FVII, FIX, and FX) without altering the activities or levels of all other clotting factors nor plasma levels of fibrinogen or von Willebrand Factor. These effects were associated with a reduction in serum and fecal levels of cholesterol and triglycerides and lower serum levels of LDL‐c. In conclusion, ASTX exerts an in vivo hypocoagulant effects mediated by the inhibition of vitamin K‐dependent factors.

中文翻译：

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亚急性虾青素给药可抑制大鼠体内维生素K依赖性凝血因子。

这项研究调查了虾青素（ASTX）对对照组大鼠凝血因子水平和活性的影响。本研究使用未经治疗或经ASTX治疗的大鼠（10 mg / kg，溶于DMSO）。每天进行10天的ASTX治疗。ASTX显着降低血小板计数和凝血酶原和活化的部分凝血活酶时间的延长值（分别为PT和aPTT）。此外，它可以显着降低血清中的维生素K水平和血浆活性以及维生素K依赖因子（FII，FVII，FIX和FX）的肝表达，而不会改变所有其他凝血因子的活性或水平，也不会改变血浆纤维蛋白原或von Willebrand因子。这些影响与血清和粪便中胆固醇和甘油三酸酯水平的降低以及血清LDL-c水平的降低有关。结论，