DNA‐based data storage has attracted attention because of its higher physical density of the data and longer retention time than those of conventional digital data storage. However, previous DNA‐based data storage lacked index features and the data quality of storage after a single access was not preserved, obstructing its industrial use. Here, DNA micro‐disks, QR‐coded micro‐sized disks that harbor data‐encoded DNA molecules for the efficient management of DNA‐based data storage, are proposed. The two major features that previous DNA‐based data‐storage studies could not achieve are demonstrated. One feature is accessing data items efficiently by indexing the data‐encoded DNA library. Another is achieving write‐once–read‐many (WORM) memory through the immobilization of DNA molecules on the disk and their enrichment through in situ DNA production. Through these features, the reliability of DNA‐based data storage is increased by allowing selective and multiple accession of data‐encoded DNA with lower data loss than previous DNA‐based data storage methods.

中文翻译：

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具有索引和一次写入多次读取（WORM）内存功能的DNA微磁盘，用于管理基于DNA的数据存储。

基于DNA的数据存储比传统的数字数据存储具有更高的数据密度和更长的保留时间，因此备受关注。但是，以前的基于DNA的数据存储缺乏索引功能，单次访问后未保存存储的数据质量，从而阻碍了其工业用途。在这里，提出了DNA微盘，QR编码的微型磁盘，这些磁盘具有数据编码的DNA分子，可以有效地管理基于DNA的数据存储。展示了以前的基于DNA的数据存储研究无法实现的两个主要功能。一种功能是通过索引数据编码的DNA库来有效地访问数据项。另一个是通过将DNA分子固定在磁盘上并通过原位DNA产生来实现一次写入多次读取（WORM）内存。