Patients with immune deficiencies can present with variable clinical phenotypes. This often translates into a significant delay in their diagnosis, and resultant patient morbidity. This review summarises the most common types of immunodeficiency disorders, primary and secondary, along with their key features. It provides a structured approach for the clinician on when to suspect an immunodeficiency, the initial investigations pathway and when a specialist referral should be considered.

中文翻译：

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如何调查可疑的成年人免疫缺陷。

免疫缺陷患者可以表现出不同的临床表型。这通常会导致他们的诊断明显延迟，并导致患者发病。这篇综述总结了最常见的免疫缺陷疾病类型，包括原发性和继发性及其主要特征。它为临床医生提供了一种结构化方法，可用于确定何时怀疑免疫缺陷，初始调查途径以及何时应考虑转诊专家。