Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) with various clinical manifestations. The characteristic of MS is that myelin is attacked by the body's immune system and increases the electrical capacity of axons, and is the primary pathophysiological mechanism of the transmission block. Studies have shown that epigenetic factors participate in the development of MS. LncRNAs are highly abundant and heterogeneous linear RNA transcripts with lengths exceeding 200 nucleotides and no protein-coding potential. Currently, pieces of evidence have demonstrated that lncRNAs have fundamental actions in multiple cellular pathways, including immune system regulation, epithelial-mesenchymal transition (EMT), cancer cell growth and metastasis, cellular homeostasis, and embryo development. It has been demonstrated that epigenetic mechanisms have an abundant role in the pathogenesis of MS in which the role of lncRNAs as epigenetic regulatory molecules in molecular processes has been proven. In this paper, we have focused on the correlation between MS and lncRNAs, the role of lncRNA in the pathogenesis of the disease, and the diagnostic and prognostic potential of lncRNA in MS.

中文翻译：

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lncRNAs在多发性硬化症中的新作用

多发性硬化症（MS）是中枢神经系统（CNS）最常见的炎性脱髓鞘疾病，具有多种临床表现。MS的特点是髓鞘受到机体免疫系统的攻击，使轴突的电容量增加，是传导阻滞的主要病理生理机制。研究表明，表观遗传因素参与了 MS 的发展。LncRNA 是高度丰富的异质线性 RNA 转录本，长度超过 200 个核苷酸，没有蛋白质编码潜力。目前，有证据表明 lncRNA 在多种细胞途径中具有基本作用，包括免疫系统调节、上皮间质转化 (EMT)、癌细胞生长和转移、细胞稳态和胚胎发育。已经证明表观遗传机制在 MS 的发病机制中具有丰富的作用，其中 lncRNA 作为表观遗传调控分子在分子过程中的作用已被证明。在本文中，我们重点讨论了 MS 和 lncRNA 之间的相关性、lncRNA 在疾病发病机制中的作用以及 lncRNA 在 MS 中的诊断和预后潜力。