Background

Gait, balance, and cognitive disorders are common in people with Multiple Sclerosis (MS). In addition, people with MS have impaired ability to concurrently perform gait/balance and cognitive tasks due to cognitive-motor interference (CMI). Clinical features of MS may affect CMI; however, the relationship between CMI and clinical features of MS remains unclear.

Research Question

Are clinical features of MS associated with CMI?

Methods

A systematic review was conducted, and four databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to March 2019 using a combination of keywords related to MS and dual-tasking/CMI. Cross-sectional or longitudinal studies that reported the association between CMI and clinical features of MS were included in the review. The correlation coefficient for the relationship between CMI and clinical features of MS were extracted and the results were categorized according to the clinical feature measured.

Results

13 studies were included in this review, of which nine investigated the association between CMI and disability and cognition, and four investigated the association between CMI and other clinical features of MS. While some studies reported that disability and cognition were negatively associated with CMI, the evidence was inconsistent regarding the magnitude and presence of these relationships. In addition, the relationship between CMI and other clinical features of MS (balance, falls risk, fatigue, anxiety, depression, pain, spasticity) remains unclear.

Significance

This review presents evidence from a small number of studies that suggests disability and cognition are negatively associated with CMI in people with MS, indicating that greater disability and cognitive dysfunction may be associated with lower dual-task performance. These findings highlight the potential importance of disability and cognition in the measurement and rehabilitation of people with dual-task impairments. However, further research is required to confirm these findings and determine the relationship between CMI and other clinical features of MS included in this review.

中文翻译：

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与多发性硬化症患者的双重任务绩效相关：系统评价。

背景

步态，平衡和认知障碍在多发性硬化症（MS）患者中很常见。另外，由于认知运动干扰（CMI），MS患者同时执行步态/平衡和认知任务的能力受损。MS的临床特征可能会影响CMI；但是，CMI与MS临床特征之间的关系仍不清楚。

研究问题

MS的临床特征与CMI相关吗？

方法

进行了系统的审查，并使用与MS和双任务/ CMI相关的关键字组合，搜索了截至2019年3月的四个数据库（CINAHL，MEDLINE，ProQuest和Web of Science核心收藏）。综述中包括横断面或纵向研究，这些研究报道了CMI与MS临床特征之间的关系。提取CMI与MS临床特征之间关系的相关系数，并根据测量的临床特征对结果进行分类。

结果

本评价包括13项研究，其中9项研究了CMI与残疾和认知之间的关联，而四项研究了CMI与MS的其他临床特征之间的关联。虽然一些研究报告说，残疾和认知与CMI呈负相关，但有关这些关系的程度和存在的证据并不一致。此外，CMI与MS的其他临床特征（平衡，跌倒风险，疲劳，焦虑，抑郁，疼痛，痉挛）之间的关系仍不清楚。

意义

这篇综述提供了来自少数研究的证据，这些证据表明残疾和认知能力与MS患者的CMI呈负相关，表明更大的残疾和认知功能障碍可能与较低的双重任务表现有关。这些发现凸显了残疾和认知能力在双任务障碍患者的测量和康复中的潜在重要性。但是，需要进一步的研究来确认这些发现，并确定CMI与本评价中包括的MS的其他临床特征之间的关系。