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The safety and efficacy of the LVIS stent for the treatment of ruptured intracranial aneurysms within 24 hours: a multicenter retrospective study
Clinical Neurology and Neurosurgery ( IF 1.8 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.clineuro.2020.106117
Xianggan Wang 1 , Haixia Xing 2 , Jing Cai 3 , Dianshi Jin 4 , Yongchun Chen 5 , Yudi Cui 6 , Shenghao Ding 6 , Jieqing Wan 6 , Yaohua Pan 6 , Guohua Mao 1 , Bing Zhao 6
Affiliation  

OBJECTIVE Stent-assisted coiling is increasingly used in the treatment of acutely ruptured intracranial aneurysms. However, the optimal timing of the stent-assisted coiling remains unknown. We aimed to investigate the safety and efficacy of the Low Profile Visualized Intraluminal Support (LVIS) stent for ruptured aneurysms treatment within 24 h comparing to the treatment between 25 and 72 h of symptom onset. PATIENTS AND METHODS We conducted a multicenter retrospective study on 110 consecutive patients with ruptured intracranial aneurysms. These patients were treated with LVIS stent within 72 h in four tertiary hospitals between January 2017 and December 2017. The timing of treatment was grouped into the treatment within 24 h and the treatment between 25 and 72 h. Baseline characteristics, periprocedural complications, angiographic results, and clinical outcomes were compared between the two groups. RESULTS A total of 101 patients were included. 49 (48.5 %) patients were treated within 24 h and 52 (51.5 %) within between 25 and 72 h. Periprocedural complications occurred in 2 (4.1 %) patients treated within 24 h compared with those in 10 (19.2 %) treated between 25-72 h (P = 0.032). No early rebleeding occurred in both groups. 45 (91.8 %) of 49 aneurysms had complete occlusion on immediate angiography compared with 46 (88.5 %) of 52 aneurysms had complete occlusion. 2 (2.0 %) aneurysms were retreated. The clinical outcomes and angiographic results did not differ between the two groups. CONCLUSIONS The LVIS stent-assisted coiling may be safe and effective in the treatment of selected patients with ruptured aneurysms within 24 h of symptom onset.

中文翻译:

LVIS支架在24小时内治疗颅内动脉瘤破裂的安全性和有效性:一项多中心回顾性研究

目的 支架辅助弹簧圈越来越多地用于治疗急性破裂的颅内动脉瘤。然而,支架辅助线圈的最佳时机仍然未知。我们旨在研究低剖面可视化管腔内支持 (LVIS) 支架在 24 小时内治疗破裂动脉瘤的安全性和有效性,与症状出现 25 至 72 小时之间的治疗相比。患者和方法 我们对 110 名连续的颅内动脉瘤破裂患者进行了多中心回顾性研究。这些患者于2017年1月至2017年12月期间在四家三级医院接受了72 h内LVIS支架治疗,治疗时机分为24 h内治疗和25-72 h治疗。基线特征、围手术期并发症、血管造影结果、并对两组的临床结果进行比较。结果共纳入101例患者。49 名 (48.5 %) 患者在 24 小时内接受治疗,52 名 (51.5 %) 患者在 25 至 72 小时内接受治疗。在 24 小时内接受治疗的患者中有 2 名(4.1 %)发生了围手术期并发症,而在 25-72 小时内接受治疗的患者中有 10 名(19.2 %)发生了围手术期并发症(P = 0.032)。两组均未发生早期再出血。49 个动脉瘤中有 45 个(91.8 %)在即刻血管造影中完全闭塞,而 52 个动脉瘤中有 46 个(88.5 %)完全闭塞。2 个 (2.0 %) 动脉瘤被撤除。两组的临床结果和血管造影结果没有差异。结论 LVIS 支架辅助弹簧圈可能是安全有效的,用于治疗特定症状出现 24 小时内动脉瘤破裂的患者。
更新日期:2020-10-01
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