Background

The innate immune response is the primary defense against influenza virus infection.

Methods

This is a prospective study carried out in children <18 years of age who were diagnosed with influenza A or influenza B infection. Demographic and clinical data, laboratory findings and cell immunophenotypes on first presentation were compared.

Results

With respect to immunophenotype, influenza A infection resulted in a higher fraction of CD14⁺ and CD4⁺IL-17A⁺cells compared to children infected with influenza B. By contrast, influenza B infection resulted in a comparatively higher percentage of double-negative CD4⁻CD8⁻ lymphocyte subsets. Influenza A infection was associated with comparatively higher percentages of CD4⁺CD25^highFoxp3⁺ and CD4⁺CD25^lowFoxp3⁺ cells. By contrast, the percentage of CD8⁺CD25^high and CD8⁺CD25^low cells was similar among patients with influenza A infection and influenza B infection.

Conclusions

An improved understanding of the fraction of regulatory T cells with influenza virus infections may provide further understandings on immune responses.

中文翻译：

---

儿童甲型流感病毒和乙型流感病毒感染的细胞免疫表型表达。

背景

天生的免疫反应是抵抗流感病毒感染的主要防御手段。

方法

这是一项对被诊断患有甲型或乙型流感感染的＜18岁儿童进行的前瞻性研究。比较首次就诊时的人口统计学和临床​​数据，实验室检查结果和细胞免疫表型。

结果

就免疫表型而言，与感染乙型流感的儿童相比，甲型流感导致的CD14 ⁺和CD4 ⁺ IL-17A ⁺细胞比例更高。相比之下，乙型流感引起的双阴性CD4-百分比更高^。 CD8 ^-淋巴细胞亚群。A型流感感染与CD4的相对较高百分比相关联⁺ CD25^高Foxp3的⁺和CD4 ⁺ CD25^低的Foxp3 ⁺细胞。相比之下，CD8 ⁺ CD25^高和CD8 ⁺ CD25的百分比甲型流感和乙型流感感染患者的^低细胞相似。

结论

对流感病毒感染的调节性T细胞比例的进一步了解可能会提供对免疫反应的进一步了解。