The release of drug from bacterial cellulose (BC) is tuned to achieve immediate and controlled delivery by using two drying strategies: freeze-drying and oven-drying. Diclofenac sodium (DCF), a hydrophilic drug, was used as the model drug and was loaded in oven-dried BC (BC-OD-DCF) and freeze-dried BC (BC-FD-DCF) to obtain sustained release and burst release, respectively. BC dried by the two methods were characterized and found to possess different structures and morphologies. The crystallinity was found to be higher for BC-OD (86 % for BC-OD and 79 % for BC-FD) while BC-FD offered higher porosity (92 % for BC-FD and 75 % for BC-OD), higher specific surface area (85 m²/g for BC-FD and 35 m²/g for BC-OD) and pore size, which altogether affects the matrix swellability, drug loading and release behaviour. The mathematical modelling of drug release kinetics supports diffusion-driven first-order release from BC-FD-DCF whereas release from BC-OD-DCF shows a super case II transport, where the buffer front travels slowly into the denser oven-dried matrix leading to a controlled release of the drug. The correlation between swelling and cumulative drug release is also discussed.

通过使用两种干燥策略，可以调节细菌从细菌纤维素（BC）的释放，以实现即时和可控的递送：冷冻干燥和烤箱干燥。双氯芬酸钠（DCF），一种亲水性药物，被用作模型药物，并装入烤箱干燥的BC（BC-OD-DCF）和冻干的BC（BC-FD-DCF）中以获得持续释放和爆发释放。 ， 分别。通过两种方法干燥的BC进行了表征，发现具有不同的结构和形态。发现BC-OD的结晶度较高（BC-OD为86％，BC-FD为79％），而BC-FD提供较高的孔隙率（BC-FD为92％，BC-OD为75％），更高比表面积（BC-FD为85 m ² / g，35 m ²为35 m ²/ g（对于BC-OD）和孔径，这些因素会共同影响基质的溶胀性，载药量和释放行为。药物释放动力学的数学模型支持从BC-FD-DCF扩散驱动的一阶释放，而从BC-OD-DCF释放则显示了II级超级转运，其中缓冲液前沿缓慢进入较密的烤箱干燥基质，控释药物。还讨论了肿胀与累积药物释放之间的相关性。