The intrinsic fragility of hydroxyapatite (HAP) restricts its wider applications for local delivery of antibiotics. The composites formed by integrating HAP with hydrogels can improve the properties of HAP. However, these reported composites not only require tedious preparation and employ organic solvent and toxic reagents, but also hardly have inherent antimicrobial property. In this study, N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite (Fmoc-L-Phe/nHAP) hybrid supramolecular hydrogels with antibacterial property and cytocompatibility was prepared by integrating nHAP as reinforcement with Fmoc-L-Phe supramolecular hydrogels. The results showed that nHAP bounds in the chamber of the gel network and adheres to the fiber of Fmoc-L-Phe due to intermolecular interaction, remarkably improving the mechanical strength of Fmoc-L-Phe supramolecular hydrogels. The results of inhibition zone experiment and MTT experiment showed that the Fmoc-L-Phe/nHAP hybrid supramolecular hydrogels possess antimicrobial property and cytocompatibility. In vitro release experiment of chlorogenic acid (CGA) from the hybrid supramolecular hydrogels was performed. The study of the release kinetics indicated that the release behavior of CGA from the hybrid supramolecular hydrogels is following Weibull model and release mechanism involved Fickian diffusion and erosion of the surface of hydrogel matrix. The release of CGA shows a good inhibition effect on S. aureus. The results show that the Fmoc-L-Phe/nHAP hybrid hydrogels with antibacterial property and cytocompatibility have promising applications as drug delivery carrier.

Due to the intrinsic fragility of hydroxyapatite (HAP), the properties of HAP could be improved by incorporation into hydrogels. However, these reported composites not only require tedious preparation and employ organic solvent and toxic reagents, but also hardly have inherent antimicrobial property. We prepared N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite (Fmoc-L-Phe/nHAP) hybrid supramolecular hydrogels by integrating nHAP as reinforcement with Fmoc-L-Phe supramolecular hydrogels. The results showed that nHAP bounds in the chamber of the gel network and adheres to the fiber of Fmoc-L-Phe due to intermolecular interaction, remarkably improving the mechanical strength of Fmoc-L-Phe supramolecular hydrogels. The results of inhibition zone experiment and MTT experiment showed that the Fmoc-L-Phe/nHAP hybrid supramolecular hydrogels possess antibacterial property and cytocompatibility. In vitro release experiment of chlorogenic acid (CGA) from the hybrid supramolecular hydrogels was performed. The study of the release kinetics indicated that the release behavior of CGA from the hybrid supramolecular hydrogels is following Weibull model and release mechanism involved Fickian diffusion and erosion of the surface of hydrogel matrix. The release of CGA shows a good inhibition effect on S. aureus. The results show that the Fmoc-L-Phe/nHAP hybrid hydrogels with antibacterial property and cytocompatibility have promising applications as drug delivery carrier.

羟磷灰石（HAP）的固有脆性限制了其在局部递送抗生素中的广泛应用。通过将HAP与水凝胶结合而形成的复合材料可以改善HAP的性能。然而，这些报道的复合材料不仅需要繁琐的制备并使用有机溶剂和有毒试剂，而且几乎没有固有的抗微生物特性。在这项研究中，通过将nHAP与Fmoc-L-Phe超分子增强剂结合在一起，制备了具有抗菌性能和细胞相容性的N-（9-氟烯基甲氧基羰基）-L-苯丙氨酸/纳米羟基磷灰石（Fmoc-L-Phe / nHAP）杂化超分子水凝胶。水凝胶。结果表明，由于分子间的相互作用，nHAP结合在凝胶网络的腔室中并粘附在Fmoc-L-Phe的纤维上，显着提高Fmoc-L-Phe超分子水凝胶的机械强度。抑制区实验和MTT实验结果表明，Fmoc-L-Phe / nHAP杂化超分子水凝胶具有抗菌性能和细胞相容性。从杂种超分子水凝胶中进行了绿原酸（CGA）的体外释放实验。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。抑制区实验和MTT实验结果表明，Fmoc-L-Phe / nHAP杂化超分子水凝胶具有抗菌性能和细胞相容性。从杂种超分子水凝胶中进行了绿原酸（CGA）的体外释放实验。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。抑制区实验和MTT实验结果表明，Fmoc-L-Phe / nHAP杂化超分子水凝胶具有抗菌性能和细胞相容性。从杂种超分子水凝胶中进行了绿原酸（CGA）的体外释放实验。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。金黄色葡萄球菌。结果表明，具有抗菌性能和细胞相容性的Fmoc-L-Phe / nHAP杂化水凝胶具有良好的应用前景。

由于羟基磷灰石（HAP）的固有脆性，可以通过将其掺入水凝胶中来改善其性能。然而，这些报道的复合材料不仅需要繁琐的制备并使用有机溶剂和有毒试剂，而且几乎没有固有的抗微生物特性。我们通过将nHAP与Fmoc-L-Phe超分子水凝胶结合作为增强剂，制备了N-（9-氟烯基甲氧基羰基）-L-苯丙氨酸/纳米羟基磷灰石（Fmoc-L-Phe / nHAP）杂化超分子水凝胶。结果表明，由于分子间的相互作用，nHAP结合在凝胶网络的腔室中并粘附到Fmoc-L-Phe的纤维上，从而显着提高了Fmoc-L-Phe超分子水凝胶的机械强度。抑制区实验和MTT实验结果表明，Fmoc-L-Phe / nHAP杂化超分子水凝胶具有抗菌性能和细胞相容性。从杂种超分子水凝胶中进行了绿原酸（CGA）的体外释放实验。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。释放动力学的研究表明，杂化超分子水凝胶的CGA释放行为遵循Weibull模型，并且释放机理涉及Fickian扩散和水凝胶基质表面的侵蚀。CGA的释放具有良好的抑制作用。金黄色葡萄球菌。结果表明，具有抗菌性能和细胞相容性的Fmoc-L-Phe / nHAP杂化水凝胶具有良好的应用前景。