There has been an influx of ads on social media seeking plaintiffs in lawsuits for harms/side-effects caused by tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC, Truvada) for PrEP. Community groups and researchers have suggested these ads may be undermining efforts to disseminate PrEP to key populations. In October 2019, we began assessing the impact of injury lawsuit ads on social media platforms in an ongoing U.S. national cohort study of HIV-negative cis men, trans men, and trans women who have sex with men. Although assessments are ongoing, given the alarming nature of our findings, we report data collected as of March 2020 (n = 2078). Most (59.9%) said they had seen ads for TDF-related lawsuits on social media. Twenty-eight percent said they would probably or definitely not start PrEP and 22.1% said they would not stay on PrEP (were they on it) as a result of seeing these ads. Next, 38.2% agreed or strongly agreed that seeing these ads made them think that TDF/FTC for PrEP was not safe. Black, Latinx, and/or multiracial individuals were most likely to be negatively impacted by the ads including perceptions that these ads made them think PrEP is not safe. In contrast, past year experience taking PrEP was positively associated with intentions to start and/or stay on PrEP despite seeing the ads. Due to forthcoming affordable/generic options, TDF/FTC is projected to become the most scalable option for disseminating PrEP to key populations. Results suggest that ads for TDF lawsuits on social media are having a negative impact on individual PrEP decision-making. Our findings highlight the urgency for accurate and balanced messaging on the benefits and risks of PrEP, so that individuals can make informed choices about whether PrEP is right for them.

社交媒体上大量广告寻求原告就富马酸替诺福韦酯/恩曲他滨（TDF/FTC，Truvada）对 PrEP 造成的危害/副作用提起诉讼。社区团体和研究人员表示，这些广告可能会破坏向重点人群传播 PrEP 的努力。2019 年 10 月，我们开始在一项针对 HIV 阴性的顺式男性、跨性别男性和与男性发生性关系的跨性别女性的美国国家队列研究中评估社交媒体平台上的伤害诉讼广告的影响。尽管评估仍在进行中，但鉴于我们发现的惊人性质，我们报告了截至 2020 年 3 月收集的数据（n  = 2078）。大多数 (59.9%) 表示他们在社交媒体上看到过 TDF 相关诉讼的广告。28% 的人表示他们可能会或绝对不会开始PrEP 和 22.1% 的人表示，他们不会因为看到这些广告而留在 PrEP（如果他们在上面的话）。接下来，38.2%同意或强烈同意看到这些广告让他们认为用于 PrEP 的 TDF/FTC 不安全。黑人、拉丁裔和/或多种族个体最有可能受到广告的负面影响，包括认为这些广告使他们认为 PrEP 不安全。相比之下，尽管看到广告，过去一年的 PrEP 经历与开始和/或继续使用 PrEP 的意图呈正相关。由于即将推出的负担得起的/通用选项，TDF/FTC 预计将成为向关键人群传播 PrEP 的最具扩展性的选项。结果表明，社交媒体上的 TDF 诉讼广告对个人 PrEP 决策产生负面影响。我们的研究结果强调了对 PrEP 的益处和风险进行准确和平衡的信息传递的紧迫性，以便个人可以就 PrEP 是否适合他们做出明智的选择。