To compare the efficacy of brinzolamide 1%/timolol 0.5% fixed drug combination (BTFC) with brinzolamide 1%/brimonidine 0.2% fixed drug combination (BBFC) among the patients with primary open-angle glaucoma (POAG). The treatment with BTFC in the Group A subjects showed a significant decrease in the intraocular pressure (p = 0.0355*) and a significant increase in the central corneal thickness (p = 0.0087*). Similarly, in the Group B subjects, the treatment with BBFC showed a significant decrease in the intraocular pressure (p = 0.0327*) and a significant increase in the central corneal thickness (p = 0.0227*). In the process of comparing both the fixed drug combinations, there was no significant difference observed in the aspect of efficacy between both the groups in the decrease of intraocular pressure (p = 0.7100) and in the increase of central corneal thickness (p = 0.4077). Both the fixed drug combinations almost showed a similar efficacy in treating the respective groups, and there is no significant difference observed in the aspect of efficacy between both the fixed drug combinations in decreasing the intraocular pressure and in increasing the central corneal thickness.

中文翻译：

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布林佐胺/噻吗洛尔与布林酰胺/溴莫尼定固定药物组合治疗原发性开角型青光眼的疗效比较研究

在原发性开角型青光眼（POAG）患者中，比较1％的浓度的替硝洛尔/ 0.5％的替莫洛尔0.5％固定药物组合（BTFC）和1％的浓度的替硝唑/溴莫尼定0.2％（BBFC）的疗效。A组受试者使用BTFC进行的治疗显示眼内压显着降低（p = 0.0355 *），中央角膜厚度显着增加（p = 0.0087 *）。同样，在B组受试者中，BBFC治疗显示眼内压显着降低（p = 0.0327 *）和中央角膜厚度显着增加（p = 0.0227 *）。在比较两种固定药物组合的过程中，两组之间在眼压降低方面的功效方面没有观察到显着差异（p = 0。7100）并增加中央角膜厚度（p = 0.4077）。两种固定药物组合在治疗各个组中几乎显示出相似的功效，并且在降低眼内压和增加中央角膜厚度方面，在两种固定药物组合之间的功效方面没有观察到显着差异。