The relationships between polymorphisms in interleukin-10 (IL-10) gene and the risk of viral hepatitis remain inconclusive. Therefore, the authors conducted so far the very first meta-analysis to robustly assess the relationships between polymorphisms in IL-10 gene and the risk of viral hepatitis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched throughly for eligible studies, and 76 genetic association studies were finally included in this meta-analysis. We noticed that rs1800871 (− 819 C/T), rs1800872 (− 592 C/A) and rs1800896 (− 1082 G/A) polymorphisms were all significantly associated with the risk of viral hepatitis in Asians, whereas only rs1800896 (− 1082 G/A) polymorphism was significantly associated with the risk of viral hepatitis in Caucasians. In further analyses by disease subtypes, we noticed that the three investigated polymorphisms were all significantly associated with the risk of both HBV and HCV. This meta-analysis demonstrates that rs1800871 (− 819 C/T), rs1800872 (− 592 C/A) and rs1800896 (− 1082 G/A) polymorphisms may influence the risk of viral hepatitis in Asians, while only rs1800896 (− 1082 G/A) polymorphism may influence the risk of viral hepatitis in Caucasians. In further analyses by disease subtypes, we noticed that the three investigated polymorphisms may influence the risk of both HBV and HCV.

中文翻译：

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IL-10基因多态性与病毒性肝炎风险之间的关联：荟萃分析。

白细胞介素 10 (IL-10) 基因多态性与病毒性肝炎风险之间的关系尚无定论。因此，作者进行了迄今为止第一个荟萃分析，通过整合先前工作的结果，有力地评估了 IL-10 基因多态性与病毒性肝炎风险之间的关系。通过Medline、Embase、Wanfang、VIP和CNKI检索符合条件的研究，最终纳入76项遗传关联研究。我们注意到 rs1800871 (− 819 C/T)、rs1800872 (− 592 C/A) 和 rs1800896 (− 1082 G/A) 多态性都与亚洲人的病毒性肝炎风险显着相关，而只有 rs1800896 (− 1082 G /A) 多态性与白种人病毒性肝炎的风险显着相关。在按疾病亚型进行的进一步分析中，我们注意到三个研究的多态性都与HBV和HCV的风险显着相关。该荟萃分析表明，rs1800871 (− 819 C/T)、rs1800872 (− 592 C/A) 和 rs1800896 (− 1082 G/A) 多态性可能影响亚洲人患病毒性肝炎的风险，而只有 rs1800896 (− 1082 G /A) 多态性可能会影响高加索人患病毒性肝炎的风险。在疾病亚型的进一步分析中，我们注意到三个研究的多态性可能会影响 HBV 和 HCV 的风险。而只有 rs1800896 (− 1082 G/A) 多态性可能影响高加索人患病毒性肝炎的风险。在疾病亚型的进一步分析中，我们注意到三个研究的多态性可能会影响 HBV 和 HCV 的风险。而只有 rs1800896 (− 1082 G/A) 多态性可能影响高加索人患病毒性肝炎的风险。在疾病亚型的进一步分析中，我们注意到三个研究的多态性可能会影响 HBV 和 HCV 的风险。