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LUAD transcriptomic profile analysis of d-limonene and potential lncRNA chemopreventive target.
Food & Function ( IF 5.1 ) Pub Date : 2020-07-28 , DOI: 10.1039/d0fo00809e Tienan Feng 1 , Qi Zhang , Qiang Li , Tengteng Zhu , Wenwen Lv , Herbert Yu , Biyun Qian
Food & Function ( IF 5.1 ) Pub Date : 2020-07-28 , DOI: 10.1039/d0fo00809e Tienan Feng 1 , Qi Zhang , Qiang Li , Tengteng Zhu , Wenwen Lv , Herbert Yu , Biyun Qian
Affiliation
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D-Limonene, a type of natural extract obtained from citrus oils, was reported to have anti-cancer effects and be well-tolerated by cancer patients. Despite arousing interest as a cancer chemopreventive substance, the transcriptomic profile of D-limonene in humans is poorly understood. Based on the results of the transcriptomic profiling, a lncRNA named protein disulfide isomerase family A member three pseudogene (PDIA3P1) was found to be regulated by D-limonene. PDIA3P1 is an oncogene verified by three lung adenocarcinoma (LUAD) datasets. The knockdown of PDIA3P1 with siRNA decreased the viability, invasion, migration, and proliferation of LUAD cells. Based on The Cancer Genome Atlas (TCGA) LUAD datasets, PDIA3P1 regulates functions and pathways mainly including lipid metabolism, immunity, and the change of the chromosome structure. This study comprehensively performs the transcriptomic analysis of the D-limonene regulation on LUAD, and reveals that PDIA3P1 may be the mediator in helping D-limonene to prevent and suppress LUAD via lipid metabolism, immunity pathway, and the change in the chromosome structure.
中文翻译：
d-柠檬烯的LUAD转录组谱分析和潜在的lncRNA化学预防靶标。
据报道，D-柠檬烯是一种从柑橘类油中提取的天然提取物，具有抗癌作用，并且被癌症患者很好地耐受。尽管引起人们对癌症化学预防物质的兴趣，但人们对D-柠檬烯的转录组概况了解甚少。根据转录组分析的结果，发现一种名为蛋白二硫键异构酶家族A成员三假基因（PDIA3P1）的lncRNA受D调控。-柠檬烯。PDIA3P1是一种癌基因，已通过三个肺腺癌（LUAD）数据集进行了验证。用siRNA敲除PDIA3P1会降低LUAD细胞的活力，侵袭，迁移和增殖。基于癌症基因组图谱（TCGA）LUAD数据集，PDIA3P1调节功能和途径，主要包括脂质代谢，免疫力和染色体结构变化。这项研究全面执行的转录组分析d上LUAD -limonene调节，并揭示了PDIA3P1可能是在帮助调解d -limonene防止和制止LUAD通过脂质代谢，免疫途径，并在染色体结构的变化。
更新日期：2020-08-19
中文翻译：
d-柠檬烯的LUAD转录组谱分析和潜在的lncRNA化学预防靶标。
据报道，D-柠檬烯是一种从柑橘类油中提取的天然提取物，具有抗癌作用，并且被癌症患者很好地耐受。尽管引起人们对癌症化学预防物质的兴趣，但人们对D-柠檬烯的转录组概况了解甚少。根据转录组分析的结果，发现一种名为蛋白二硫键异构酶家族A成员三假基因（PDIA3P1）的lncRNA受D调控。-柠檬烯。PDIA3P1是一种癌基因，已通过三个肺腺癌（LUAD）数据集进行了验证。用siRNA敲除PDIA3P1会降低LUAD细胞的活力，侵袭，迁移和增殖。基于癌症基因组图谱（TCGA）LUAD数据集，PDIA3P1调节功能和途径，主要包括脂质代谢，免疫力和染色体结构变化。这项研究全面执行的转录组分析d上LUAD -limonene调节，并揭示了PDIA3P1可能是在帮助调解d -limonene防止和制止LUAD通过脂质代谢，免疫途径，并在染色体结构的变化。
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