Sensor platforms that exploit the fibrous textile threads as substrates offer great promise since they can be directly sewn, woven or stitched on to any clothing. They can also be placed directly in intimate contact with the skin. In this work, we present a thread-based sensing platform in the form of a multiplexed sensing patch for continuous simultaneous on-skin monitoring of sweat. The patch performs real-time, on-body measurements of important biomarkers present in sweat such as electrolytes (sodium and ammonium ions), metabolites (lactate) and acidity (pH). Flexible threads coated with conductive inks were used as sensing electrodes. Selective potentiometric detection of electrolytes and pH was made possible through ion-selective membrane deposition and pH-sensitive polyaniline coating on threads, respectively. An amperometric enzymatic sensing scheme with lactate oxidase was used for the detection of lactate. An array of the thread sensors is integrated onto a patch with connectivity to a miniaturized circuit module containing a potentiostat, microprocessor and wireless circuitry for wireless smartphone readout. Extensive in vitro validation and an in vivo human pilot study involving a maximal exertion test show the promise of this platform for real-time physiological monitoring of human performance/fitness under stress, as well as diagnostic monitoring through sweat analysis.

利用纤维纺织线作为基材的传感器平台具有很大的前景，因为它们可以直接缝制，编织或缝制在任何衣服上。它们也可以直接与皮肤紧密接触放置。在这项工作中，我们以多路感应贴片的形式提出了一种基于线程的感测平台，用于连续同时对汗液进行皮肤监测。该贴片可对汗液中存在的重要生物标志物（例如电解质（钠和铵离子），代谢物（乳酸盐）和酸度（pH））进行实时的体内测量。涂有导电油墨的柔性线用作感应电极。分别通过离子选择性膜沉积和在线上对pH敏感的聚苯胺涂层，可以选择性地检测电解质和pH。使用乳酸氧化酶的安培酶促传感方案检测乳酸。一系列线程传感器集成到一个补丁上，并与微型电路模块相连，该模块包含稳压器，微处理器和用于无线智能手机读取的无线电路。广泛的体外验证和涉及最大运动量测试的体内人类试验研究表明，该平台有望用于实时生理监测人体在压力下的表现/健康状况，并通过汗液分析进行诊断监测。