Mantle cell lymphoma is a rare, aggressive, and largely incurable form of non-Hodgkin lymphoma. There are a number of well-characterized prognostic features but nothing that can help guide therapy. Treatment with chemotherapy is generally effective in the short term, but relapse is inevitable and subsequent treatment is challenging. The use of Bruton tyrosine kinase inhibitors, however, has transformed practice. These agents are highly active in relapsed disease and are very well-tolerated drugs. Chemotherapy-free combinations using Bruton tyrosine kinase inhibitors look very exciting and will likely evolve to be part of frontline care in the future.

套细胞淋巴瘤是一种罕见的，侵袭性的且基本上无法治愈的非霍奇金淋巴瘤。有许多特征明确的预后特征，但没有什么可以帮助指导治疗。在短期内，化学疗法通常是有效的，但复发是不可避免的，后续的治疗也具有挑战性。但是，使用布鲁顿酪氨酸激酶抑制剂已经改变了实践。这些药物在复发性疾病中具有很高的活性，并且是耐受性非常好的药物。使用Bruton酪氨酸激酶抑制剂的无化学疗法组合看起来非常令人兴奋，并且将来可能会成为一线治疗的一部分。