ABSTRACT The establishment of nucleic acid amplification technology and functional nucleic acid aptamers promote the development of detection techniques. In particular, the detection displayed promise for broader application, as well as improved specificity ad higher sensitivity when combined with immunoassays (IA). This review introduced the novel immuno-nucleic acid (INA) cooperative detection technology, which is currently applied in the field of food safety for the recognition of residues of veterinary drugs and pesticides, biological toxins, pathogenic microorganisms, genetically modified foods (GMF), environmental pollutants, and more. Ultimately, the prospects for future development prospects, as well as the potential advantages of this technology were presented. Graphic. Magnifying glass, Taiji, Circular ring, Octagonal flowers, and Seven circular illustrations. Magnifying glass represents immunoassay (IA). Nucleic acid amplification and functional nucleic acid aptamers represent the yellow part and the green part of Taiji, respectively. The light blue circular ring is written “more sensitive, more specific, more rapid, low cost, high throughput” shows advantages of immunoassays combined nucleic acid amplification and functional nucleic acid aptamers. Each extended petals of octagonal flowers represent the application of immuno-nucleic acid cooperative detection technology for food safety in pesticide residues, veterinary drug residues, toxin, pathogenic microorganisms, genetically modified food, food additive, as well as allergen and harmful substance, respectively. Finally, the seven circular illustrations display the most representative elements in seven detection fields above intuitively. GRAPHICAL ABSTRACT

中文翻译：

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用于食品安全的新型免疫核酸协同检测技术

摘要 核酸扩增技术和功能核酸适体的建立促进了检测技术的发展。特别是，该检测显示出更广泛应用的前景，以及与免疫测定 (IA) 结合时提高的特异性和更高的灵敏度。本综述介绍了目前应用于食品安全领域的新型免疫核酸（INA）协同检测技术，用于识别兽药和农药残留、生物毒素、病原微生物、转基因食品（GMF）、环境污染物等。最后，提出了未来发展前景的前景，以及该技术的潜在优势。形象的。放大镜，太极，圆环，八角花，和七个圆形插图。放大镜代表免疫测定 (IA)。核酸扩增和功能核酸适体分别代表太极拳的黄色部分和绿色部分。淡蓝色圆环写着“更灵敏、更特异、更快速、低成本、高通量”，体现了免疫分析结合核酸扩增和功能核酸适体的优势。八角花的每一片花瓣代表着免疫核酸协同检测技术在食品安全中的应用，分别是农药残留、兽药残留、毒素、病原微生物、转基因食品、食品添加剂，以及过敏原和有害物质。最后，七个圆形插图直观地展示了上面七个检测领域中最具代表性的元素。图形概要