Actigraphy, an objective measure of motor activity, reliably indexes increased movement levels in attention-deficit/hyperactivity disorder (ADHD) and may be useful for diagnosis and treatment-monitoring. However, actigraphy has not been examined in complex neurodevelopmental conditions. This study used actigraphy to objectively measure movement levels in individuals with a complex neurodevelopmental genetic disorder, tuberous sclerosis (TSC). Thirty participants with TSC (11–21 years, 20 females, IQ = 35–108) underwent brief (approximately 1 h) daytime actigraph assessment during two settings: movie viewing and cognitive testing. Multiple linear regressions were used to test associations between movement measurements and parent-rated ADHD symptoms. Correlations were used to examine associations between actigraph measures and parent-rated ADHD symptoms and other characteristics of TSC (symptoms of autism spectrum disorder (ASD), intellectual ability (IQ), epilepsy severity, cortical tuber count). Higher movement levels during movies were associated with higher parent-rated ADHD symptoms. Higher ADHD symptoms and actigraph-measured movement levels during movies were positively associated with ASD symptoms and negatively associated with IQ. Inter-individual variability of movement during movies was not associated with parent-rated hyperactivity or IQ but was negatively associated with ASD symptoms. There were no associations with tuber count or epilepsy. Our findings suggest that actigraph-measured movement provides a useful correlate of ADHD in TSC.

中文翻译：

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肌动图测量的运动与患有或不患有智障和自闭症谱系障碍（ASD）的结节性硬化症（TSC）年轻人的注意缺陷/多动障碍（ADHD）症状相关。

动作学是运动活动的客观衡量指标，可以可靠地指示注意力不足/多动症（ADHD）中运动水平的升高，对诊断和治疗监测很有用。但是，尚未在复杂的神经发育条件下检查书法。这项研究使用书法术来客观地测量具有复杂神经发育遗传疾病结节性硬化症（TSC）的个体的运动水平。30名TSC参与者（11–21岁，20名女性，智商= 35–108）在以下两种情况下进行了简短的（约1小时）日间活动记录仪评估：电影观看和认知测试。多元线性回归用于检验运动测量值与父母评定的多动症症状之间的关联。相关性用于检查活动记录仪测量值与父母评分的ADHD症状和TSC其他特征（自闭症谱系障碍（ASD），智力（IQ），癫痫严重程度，皮质结节计数）之间的关联。电影中较高的运动水平与较高的父母多动症症状相关。电影中较高的ADHD症状和活动记录仪测量的运动水平与ASD症状呈正相关，与IQ呈负相关。电影过程中个体间的运动差异与父母评定的活动过度或智商无关，但与ASD症状负相关。与块茎计数或癫痫没有关系。我们的研究结果表明，通过活动记录仪测量的运动提供了TSC中ADHD的有用关联。