The merger of cross-electrophile coupling and asymmetric catalysis provides a novel approach to the preparation of optically active compounds. This method is often endowed with high step economy, mild conditions, and excellent tolerance of functional groups. Recent advances in the research field of nickel-catalyzed asymmetric cross-electrophile coupling reactions are highlighted in this concise Synpacts article. 1 Introduction 2 Asymmetric Cross-Electrophile Coupling Reactions between Organohalides 3 Asymmetric Electrophilic Ring-Opening Reactions 4 Asymmetric Electrophilic Difunctionalization of Alkenes 4.1 Two-Component Electrophilic Difunctionalization of Alkenes Involving Arylnickelation as an Enantiodetermining Step 4.2 Two-Component Electrophilic Difunctionalization of Alkenes Involving Carbamoylnickelation as an Enantiodetermining Step 4.3 Three-Component Electrophilic Difunctionalization of Alkenes 5 Asymmetric Electrophilic Functionalization of Carbonyl Compounds 6 Summary

中文翻译：

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镍催化的不对称交叉电化学偶联反应

交叉亲电偶联和不对称催化的结合为制备光学活性化合物提供了一种新方法。这种方法通常具有步骤经济性高、条件温和、官能团耐受性好等优点。这篇简洁的 Synpacts 文章重点介绍了镍催化不对称交叉亲电偶联反应研究领域的最新进展。1 引言 2 有机卤化物之间的不对称交叉电偶偶联反应 3 不对称亲电开环反应 4 烯烃的不对称亲电双官能化 4.1 烯烃的双组分亲电双官能化，包括芳基镍化作为对映决定步骤 4.2 烯烃的双组分亲电双官能化作为羧基镍的双组分亲电双官能化对映测定步骤 4。