Self‐Assembled Nanoparticles: Exciting Platforms for Vaccination,Biotechnology Journal

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Self‐Assembled Nanoparticles: Exciting Platforms for Vaccination
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-07-28 , DOI: 10.1002/biot.202000087
Jingdi Pan _{1,

2} , Zongqiang Cui _{1,

2}

Affiliation

Vaccination is successfully advanced to control several fatal diseases and improve human life expectancy. However, additional innovations are required in this field because there are no effective vaccines to prevent some infectious diseases. The shift from the attenuated or inactivated pathogens to safer but less immunogenic protein or peptide antigens has led to a search for effective antigen delivery carriers that can function as both antigen vehicles and intrinsic adjuvants. Among these carriers, self‐assembled nanoparticles (SANPs) have shown great potential to be the best representative. For the nanoscale and multiple presentation of antigens, with accurate control over size, geometry, and functionality, these nanoparticles are assembled spontaneously and mimic pathogens, resulting in enhanced antigen presentation and increased cellular and humoral immunity responses. In addition, they may be applied through needle‐free routes due to their adhesive ability, which gives them a great future in vaccination applications. This review provides an overview of various SANPs and their applications in prophylactic vaccines.

中文翻译：

自组装纳米颗粒：令人兴奋的疫苗接种平台

疫苗接种已经成功地进行了控制，以控制几种致命疾病并提高了人们的预期寿命。但是，由于没有有效的疫苗来预防某些传染病，因此在该领域还需要其他创新。从减毒或灭活的病原体向更安全但免疫原性较低的蛋白质或肽抗原的转变，导致人们寻找可同时充当抗原载体和内在佐剂的有效抗原递送载体。在这些载体中，自组装纳米颗粒（SANP）已显示出成为最佳代表的巨大潜力。为了对抗原进行纳米级和多次呈递，并精确控制大小，几何形状和功能，这些纳米颗粒会自发组装并模拟病原体，导致抗原呈递增加，细胞和体液免疫反应增强。另外，由于它们的粘合能力，它们可以通过无针途径应用，这为它们在疫苗接种应用中具有广阔的前景。这篇综述概述了各种SANP及其在预防性疫苗中的应用。

更新日期：2020-07-28

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