Phenoxazine-based Near-infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells.,Chemistry - An Asian Journal

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Phenoxazine-based Near-infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-07-28 , DOI: 10.1002/asia.202000783
Yang Shen ₁ , Wubin Zheng ₁ , Yusi Yao ₁ , Dongmei Wang ₁ , Guanglei Lv ₁ , Chunxia Li _{1,

2}

Affiliation

Abstract: It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn‐off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn‐on” near‐infrared (NIR) fluorescent probe PZ‐N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu²⁺). Upon the addition of Cu²⁺, the probe could quickly react with Cu²⁺ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ‐N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ‐N was capable of effectively detecting Cu²⁺ in living cells.

中文翻译：

基于苯氧嗪的近红外荧光探针，用于特异性检测活细胞中的铜（II）离子。

摘要：众所周知，铜离子在各种生理过程中起着至关重要的作用。然而，多种人类疾病与铜超载紧密相关。尽管有许多能够检测铜离子的荧光探针，但是由于铜（II）离子的荧光猝灭作用，大多数探针都是“关闭”探针，导致灵敏度很低。本文中，设计并合成了一种新型的基于吩恶嗪的“开启”近红外（NIR）荧光探针PZ-N，用于选择性检测铜（II）离子（Cu ²⁺）。添加Cu ^2+后，探针可以迅速与Cu ²⁺反应并发出强烈的荧光，颜色从无色变为明显的蓝色。此外，PZ-N探针显示出良好的水溶性，高选择性和出色的灵敏度，并且对铜（II）离子的检测限较低（1.93 nM）。更重要的是，PZ-N能够有效检测活细胞中的Cu ²⁺。

更新日期：2020-09-14

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