Tithonia diversifolia aqueous fraction plays a protective role against alloxan-induced diabetic mice via modulating GLUT2 expression,South African Journal of Botany

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Tithonia diversifolia aqueous fraction plays a protective role against alloxan-induced diabetic mice via modulating GLUT2 expression
South African Journal of Botany ( IF 2.7 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.sajb.2020.07.007
Lanchakon Chunudom , Montakarn Thongsom , Naymul Karim , Md. Atiar Rahman , Mohammad Nasiruddin Rana , Jitbanjong Tangpong

Abstract Tithonia diversifolia, a well-known member of the sunflower family and is used as traditional medicine for the treatment of several diseases including diabetes. This study, therefore, evaluated the anti-diabetic effect of T. diversifolia aqueous fraction (TdF) in alloxan-induced diabetic mice through an investigation of glucose transporter 2 (GLUT2) expression. Alloxan-induced diabetic mice were treated with TdF 100, 200, and 300 mg/kg body weight (BW) and glibenclamide 60 mg/kg BW for a 30 days intervention study. Collected blood and liver samples of experimental animals were undertaken to analyze metabolic parameters, mRNA and protein expressions of GLUT2. Diabetic mice treated with TdF treatments were significantly (P

中文翻译：

Tithonia diversifolia 水部分通过调节 GLUT2 表达对四氧嘧啶诱导的糖尿病小鼠发挥保护作用

摘要 Tithonia diversifolia 是向日葵科的著名成员，被用作治疗包括糖尿病在内的多种疾病的传统药物。因此，本研究通过对葡萄糖转运蛋白 2 (GLUT2) 表达的研究，评估了四氧嘧啶诱导的糖尿病小鼠中 T. diversifolia 水性组分 (TdF) 的抗糖尿病作用。四氧嘧啶诱导的糖尿病小鼠用 TdF 100、200 和 300 mg/kg 体重 (BW) 和格列本脲 60 mg/kg BW 进行治疗，为期 30 天的干预研究。采集实验动物的血液和肝脏样本以分析GLUT2的代谢参数、mRNA和蛋白质表达。用 TdF 治疗的糖尿病小鼠显着（P

更新日期：2020-09-01

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