BACKGROUND As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature. OBJECTIVE To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT. METHODS In three Italian MS centers (2012-2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude. RESULTS Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; <25% about relapses. Median acceptable risk of death for both hypothetical drug scenarios was 1:10,000; 19-20% would not take any risk related to DMT. Regression analysis revealed that being male, more educated, and with higher impulsivity/sensation-seeking propensity was significantly associated with a higher risk attitude. CONCLUSIONS Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.

中文翻译：

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多发性硬化症患者面临不同疾病修饰治疗方案选择的风险态度和个性

背景随着可用的疾病改善疗法 (DMT) 的增加，评估收益/风险带来了更大的困难，需要 MS (PwMS) 患者在选择治疗方法时发挥关键作用。尽管个人对风险的态度可以预测这种评估，但 MS 文献中很少研究它与个性的关系。目的 前瞻性评估 PwMS 选择 DMT 的风险态度和个性特征。方法 在三个意大利 MS 中心（2012-2015 年），420 名 PwMS 完成了一份关于社会人口统计学变量、个性和标准赌博问题的临时问卷，以通过两种假设的药物情景评估 MS 和 DMT 相关风险。我们评估了先前收集的社会人口/临床特征和人格因素对风险态度的影响。结果 几乎一半的参与者主要关注进行性多灶性白质脑病；<25% 关于复发。两种假设的药物情景中可接受的死亡风险中位数为 1:10,000；19-20% 不会承担与 DMT 相关的任何风险。回归分析显示，男性、受过更多教育、具有更高的冲动/追求感觉的倾向与更高的风险态度显着相关。结论社会人口统计学和人格因素都会影响 PwMS 面临不同 DMT 情景的风险态度。这些发现可能会影响为 PwMS 选择最佳治疗方案的共同决策过程。19-20% 不会承担与 DMT 相关的任何风险。回归分析显示，男性、受过更多教育、具有更高的冲动/追求感觉的倾向与更高的风险态度显着相关。结论社会人口统计学和人格因素都会影响 PwMS 面临不同 DMT 情景的风险态度。这些发现可能会影响为 PwMS 选择最佳治疗方案的共同决策过程。19-20% 不会承担与 DMT 相关的任何风险。回归分析显示，男性、受过更多教育、具有更高的冲动/追求感觉的倾向与更高的风险态度显着相关。结论社会人口统计学和人格因素都会影响 PwMS 面临不同 DMT 情景的风险态度。这些发现可能会影响为 PwMS 选择最佳治疗方案的共同决策过程。