Abstract

This paper proposes a method of one-step synthesis of a magnetic nanocomposite based on hydroxyapatite and iron oxide using the modified stoichiometric titration method. The possibility is shown of modifying the proposed method for one-step synthesis of the magnetic nanocomposite containing bioactive compound (BAC) from a 2-arylaminopyrimidine series. The composition, morphology, structure, and magnetic characteristics of the nanocomposites with and without BAC have been evaluated. The kinetics of the BAC release in a solution simulating the stomach environment has been studied. The reported composite is promising for biomedical applications as a tool for targeted drug delivery.

中文翻译：

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基于羟基磷灰石，磁铁矿和2-芳基氨基嘧啶衍生物的复合材料的合成与性能

摘要

本文提出了一种使用改进的化学计量滴定法一步合成基于羟基磷灰石和氧化铁的磁性纳米复合材料的方法。显示了修改提议的方法的可能性，该方法用于一步合成2-甲基氨基嘧啶系列含生物活性化合物（BAC）的磁性纳米复合材料。已经评估了具有和不具有BAC的纳米复合材料的组成，形态，结构和磁性。已经研究了在模拟胃环境的溶液中BAC释放的动力学。报道的复合材料有望成为生物医学应用中靶向药物输送的工具。