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Synthesis and Properties of Composites Based on Hydroxyapatite, Magnetite, and 2-Arylaminopyrimidine Derivatives
Nanotechnologies in Russia Pub Date : 2020-07-28 , DOI: 10.1134/s1995078019060089 Zh. V. Ignatovich , Kh. A. Novik , A. V. Abakshonok , E. V. Koroleva , A. E. Shumskaya , E. Yu. Kaniukov
中文翻译:
基于羟基磷灰石,磁铁矿和2-芳基氨基嘧啶衍生物的复合材料的合成与性能
更新日期:2020-07-28
Nanotechnologies in Russia Pub Date : 2020-07-28 , DOI: 10.1134/s1995078019060089 Zh. V. Ignatovich , Kh. A. Novik , A. V. Abakshonok , E. V. Koroleva , A. E. Shumskaya , E. Yu. Kaniukov
Abstract
This paper proposes a method of one-step synthesis of a magnetic nanocomposite based on hydroxyapatite and iron oxide using the modified stoichiometric titration method. The possibility is shown of modifying the proposed method for one-step synthesis of the magnetic nanocomposite containing bioactive compound (BAC) from a 2-arylaminopyrimidine series. The composition, morphology, structure, and magnetic characteristics of the nanocomposites with and without BAC have been evaluated. The kinetics of the BAC release in a solution simulating the stomach environment has been studied. The reported composite is promising for biomedical applications as a tool for targeted drug delivery.中文翻译:
基于羟基磷灰石,磁铁矿和2-芳基氨基嘧啶衍生物的复合材料的合成与性能