Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab’)₂ plus Bioporter® showed 70% survival compared to the control group, suggesting that transfection of anti-RABV antibodies to the brain may prevent or delay the spread of RABV at an early stage of infection. This result may provide important protocol results in intracellular antibody delivery to prevent the fatal outcome of the disease.

中文翻译：

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抗狂犬病病毒抗体的脑内转染是治疗狂犬病的有效疗法。

狂犬病是一种神经系统疾病，具有 100% 的致死率。一些在多种药物治疗后幸存下来的罕见人类患者有严重的后遗症。本研究表明，在接种RABV 48 小时后，与对照组相比，脑内注射抗 RABV F (ab') ₂加 Bioporter® 的小鼠存活率达 70%，这表明将抗 RABV 抗体转染至大脑可能在感染的早期预防或延迟 RABV 的传播。这一结果可能为细胞内抗体递送提供重要的协议结果，以防止疾病的致命后果。