For point-of-care diagnosis of tuberculosis (TB), current TB diagnostic approaches need to be further improved for achieving an accurate diagnosis that is rapid and low-cost. This paper presents an immuno-resistive sensor on a plastic film for inexpensive, simple TB screening. The sensor is composed of single-walled carbon nanotubes (SWCNTs) functionalized with polyclonal antibodies raised against the MPT64 surface antigen from Mycobacterium tuberculosis (MTB). The target analyte of either MTB or MPT64 is spiked in tongue swab and sputum samples. Under optimized conditions, targets are directly detected from tongue swab samples by resistive measurement. Target analytes spiked into human sputa are enriched with a magnetic bead protocol followed by resistive detection. This highly sensitive film sensor will facilitate rapid TB screening with the added benefits of a small form factor, simple operation, low power requirement, and low cost.

中文翻译：

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基于碳纳米管的薄膜电阻传感器，用于结核病的即时筛查。

对于结核病的即时诊断，需要进一步改进当前的结核病诊断方法，以实现快速，低成本的准确诊断。本文提出了一种在塑料薄膜上的免疫抵抗传感器，用于廉价，简单的结核病筛查。该传感器由单壁碳纳米管（SWCNT）组成，这些碳纳米管利用针对结核分枝杆菌的MPT64表面抗原产生的多克隆抗体进行了功能化（MTB）。将MTB或MPT64的目标分析物加标在舌拭子和痰液样本中。在最佳条件下，可通过电阻测量直接从舌拭样本中检测目标。掺入人类痰液中的目标分析物富含磁珠方案，然后进行电阻检测。这种高度灵敏的胶片传感器将有助于快速进行结核病筛查，并具有体积小，操作简单，功耗低和成本低的优点。