Cisplatin (CP), an anticarcinogenic agent, is declared to have side effects including cardiotoxicity. Naringin (NA), a flavonoid, was shown to have strong antioxidant structure and anti-inflammatory characteristics. Pupose of our study was to investigate the protective effects of NA on Caisplatin-induced cardiotoxicity. Sprague-Dawley male rats in the range of 220-250 g were exerted in this experimental studies. The rats used in experiment separated to 5 groups (10 in each one): Control, CP, NA100+CP, NA200+CP and NA200. The groups received drugs for 14 days. The rats were decapitated on 15th day. Cardiac tissue and blood samples was taken. When the cardiac tissue was assessed for oxidative stress, a prominent increase was found in CP group than other groups (p<0.05). It was assigned that serum CK, CK-MB, LDH, AST and ALT activities and levels of cytokines (TNF-alpha, IL-8, IL-1β and IL-6) in the cardiac tissue, a significant increase was found in CP group than control group (p<0.05). In both control and NA200+CP groups, similar values obtained for comparative values. Caspase 3 and iNOS activity were significantly raised for CP group, compared to NA100+CP and NA200+CP, control groups. NA has a protective effect on CP-induced heart injury. It has been determined that NA prevents CP-induced apoptosis in the heart.

中文翻译：

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柚皮苷对顺铂引起的心脏损害的抗氧化，抗炎和抗凋亡作用

顺铂（CP）是一种抗癌剂，据称具有副作用，包括心脏毒性。类黄酮柚皮素（NA）具有很强的抗氧化结构和抗炎特性。我们研究的目的是研究NA对凯铂诱导的心脏毒性的保护作用。在该实验研究中使用了220-250g范围内的Sprague-Dawley雄性大鼠。实验中使用的大鼠分为5组（每组10只）：对照组，CP，NA100 + CP，NA200 + CP和NA200。各组接受药物治疗14天。在第15天将大鼠断头。采集心脏组织和血液样本。当评估心脏组织的氧化应激时，CP组比其他组显着增加（p<0.05）。据确定，心脏组织中的血清CK，CK-MB，LDH，AST和ALT活性以及细胞因子（TNF-α，IL-8，IL-1β和IL-6）水平显着增加。组比对照组（p <0.05）。在对照组和NA200 + CP组中，获得的相似值均是比较值。与NA100 + CP和NA200 + CP对照组相比，CP组的胱天蛋白酶3和iNOS活性显着提高。NA对CP诱发的心脏损伤具有保护作用。已经确定NA可以防止CP诱导的心脏细胞凋亡。