According to new investigations, oregano oil nasal spray can be used to treat patients with chronic rhinosinusitis (CRS) effectively. The current study examines the incremental effect of oregano oil and the use of Persian medicine lifestyle modification (PML). 75 adult patients with CRS participated in this study; the clinical trial was done in Otolaryngology Clinic of the Fifth Azar Hospital from January 30 to June 25, 2018. A kit including saline bottle, identical PML instruction, and identical nasal sprays containing either oregano oil (intervention group), fluticasone (control group) or sesame oil (placebo group) was given to all participants for 4 weeks. The reduction of mean change in SNOT-22 scores were 51.52 (95% CI, -55.79 to -47.24), 21.60 (95% CI, -25.48 to -17.71) and 11.84 (95% CI, -13.18 to -10.51) points for those in the oregano, fluticasone and placebo group, respectively. The mean difference of oregano to fluticasone and oregano to placebo group were 29.92 (-35.78 to -24.05) to 39.68 (-45.54 to -33.81) point, respectively, in favor of the oregano group. This study shows that oregano oil results in clinically meaningful benefits beyond those of fluticasone and sesame oil for patients with CRS without nasal polyps. Nonetheless, its generalization should be explored further.

中文翻译：

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牛至油（牛至）对慢性鼻-鼻窦炎的影响：一项随机，双盲，临床试验

根据新的研究，牛至油鼻喷雾剂可用于有效治疗慢性鼻-鼻窦炎（CRS）患者。当前的研究检查了牛至油的增量作用以及波斯医学生活方式的改变（PML）的使用。75名成人CRS患者参加了这项研究。该临床试验于2018年1月30日至6月25日在第五阿扎尔医院的耳鼻喉科诊所进行。试剂盒包括生理盐水瓶，相同的PML说明书和相同的鼻喷雾剂，其中包含牛至油（干预组），氟替卡松（对照组）或芝麻油（安慰剂组）给予所有参与者4周。SNOT-22得分的平均变化减少为51.52（95％CI，-55.79至-47.24），21.60（95％CI，-25.48至-17.71）和11.84（95％CI，-13.18至-10.51）点对于那些牛至 氟替卡松组和安慰剂组。牛至与氟替卡松组和牛至与安慰剂组的平均差分别为29.92（-35.78至-24.05）至39.68（-45.54至-33.81）点，有利于牛至组。这项研究表明，对于没有鼻息肉的CRS患者而言，牛至油在临床上具有优于氟替卡松和芝麻油的益处。尽管如此，应进一步探索其概括性。