Benzamides and substituted benzamides are versatile compounds used in a range of pharmacological and biological active intermediate chemicals for conversion to fine chemicals. The current syntheses protocols are chemical and energy intensive. Herein is present an effortless solvent free microwave assisted synthesis of twenty N-(aryl)-substituted benzamides having good to excellent yields with short reaction time, high selectivity and occurring under milder conditions with high atom efficiency. The structures of the prepared compounds have been confirmed using melting point, FT-IR, ¹H and ¹³C NMR spectral data which are in good agreement with the previously reported literature. Unlike conventional methods, the present novel process protocol offers cleaner, greener technologies in which effluent streams are minimized.

中文翻译：

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在无溶剂条件下轻松地微波合成N-（芳基）取代的苯甲酰胺

苯甲酰胺和取代的苯甲酰胺是用途广泛的化合物，可用于一系列药理和生物活性中间化学品，以转化为精细化学品。当前的合成方案是化学和能量密集的。本文提出了二十种N-（芳基）-取代的苯甲酰胺的无溶剂的无溶剂微波辅助合成，其具有良好至优异的产率，短的反应时间，高的选择性并且在温和的条件下以高的原子效率发生。使用熔点，FT-IR，¹ H和¹³确认了所制备化合物的结构与先前报道的文献非常一致的13 C NMR光谱数据。与常规方法不同，本新颖的工艺规程提供了更清洁，更绿色的技术，其中使废水流最小化。