Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs.

中文翻译：

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新型苯并[4,5]咪唑并[1,2-a]嘧啶-[4,5-d]嘧啶衍生物的合成

通过2-氨基-4-芳基-4,10-二氢苯并[4 ]的反应，实现了新型苯并[4,5]咪唑并[1,2- a ]嘧啶[4,5- d ]嘧啶5/6的合成。 ，5]咪唑并[1,2 - a ]嘧啶-3-腈4与甲醛/脲。关键中间体4是通过三组分一锅法使2-氨基苯甲醛1与芳族醛和丙二腈反应制得的。已经评价了新合成的标题化合物5/6的体外抗菌活性。与标准药物相比，化合物5和6表现出强大的抗菌活性。