Interest in the biological applications of oleochemicals has resulted in the development of new heterocyclic compounds from the fatty acids which are renewable raw materials. In the present study the synthesis of hybrid compounds by involving fatty acids, indole-3-acetic acid (heteryl) and trimethoxy benzoic acid (aryl) to derive 2, 5-substituted 1,3,4-oxadiazole moiety using molecular hybridization approach has been carried out. A series of novel 2-((1H-indol-3-yl) methyl)-5-alkyl-1,3,4-oxadiazoles 4a-j and 2-alkyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole 8a-j analogues have been synthesized and evaluated for their cytotoxicity against A549, MCF-7 and HeLa cell lines. Almost all the tested compounds reveal cytotoxicity against all the cell lines, especially 2-((1H-indol-3-yl) methyl)-5-alkyl-1,3,4-oxadiazoles based compounds (4c, 4d, 4e) which display potent inhibitory activity with IC₅₀ values ranging between 8.26 to 11.36 μM.

中文翻译：

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新型2-（（1H-吲哚-3-基）甲基）-5-烷基-1,3,4-恶二唑和2-烷基-5-（3,4,5-三甲氧基苯基）-1的合成，细胞毒性评估，3,4-恶二唑衍生物

人们对油脂化学产品的生物学应用产生了兴趣，从而从可再生原料脂肪酸中开发出了新的杂环化合物。在本研究中，通过使用分子杂交方法，通过涉及脂肪酸，吲哚-3-乙酸（杂基）和三甲氧基苯甲酸（芳基）来合成2，5取代的1,3,4-恶二唑部分，可以合成杂化化合物。进行了。一系列新颖的2-（（（1 H-吲哚-3-基）甲基）-5-烷基-1,3,4-恶二唑4a-j和2-烷基-5-（3,4,5-三甲氧基苯基） -1,3,4-恶二唑8a-j已合成类似物并评估了其对A549，MCF-7和HeLa细胞系的细胞毒性。几乎所有测试的化合物都显示出对所有细胞系的细胞毒性，尤其是基于2-（（（1 H-吲哚-3-基）甲基）-5-烷基-1,3,4-恶二唑的化合物（4c，4d，4e）表现出有效的抑制活性，IC ₅₀值在8.26至11.36μM之间。