A series of 3-methyl-4-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)isoxazol-5(4H)-one derivatives have been efficiently synthesized by environmentally benign, one-pot three component condensation of substituted 1,3-diaryl-1H-pyrazole-4-carboxyaldehyde, β-keto ester and hydroxyl amine hydrochloride in the presence of ionic liquid [HNMP][HSO₄] as a catalyst in ethanol. These derivatives have been synthesized by conventional, ultrasound and microwave irradiation methods. The combination of ionic liquid with ultrasound as well as microwave irradiation makes the protocol fascinating and environmentally benign. In addition, it has several benefits such as simple work-up procedure, clean reaction profile, short reaction time and good yields.

中文翻译：

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离子液体多组分反应一锅法合成异恶唑酮衍生物

一系列3-甲基-4-（（3-芳基-1-苯基-1 H-吡唑-4-基）亚甲基）异恶唑-5（4 H）-衍生物已通过环境友好的方法有效合成，离子液体[HNMP] [HSO ₄ ]存在下的1,3-二芳基-1 H-吡唑-4-羧醛，β-酮酸酯和盐酸羟胺的三组分缩合反应]作为乙醇中的催化剂。这些衍生物已经通过常规的，超声和微波辐射方法合成。离子液体与超声波以及微波辐射的结合使该方案引人入胜且对环境无害。此外，它还具有一些好处，例如后处理步骤简单，反应曲线干净，反应时间短和产率高。