A four-step preparation of compounds containing a pyrimidine moiety is presented. This synthesis involves especially a Vilsmeier–Haack reaction and the synthesized compounds screened for their antibacterial activity against Gram-positive and Gram-negative organisms, as well as for antifungal activities. Structures of all the newly synthesized compounds were confirmed by their FTIR, ¹H NMR, mass spectral and elemental analysis data. Some of the newly synthesized compounds show excellent antimicrobial activity and appear to be the most proficient members of the series.

中文翻译：

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新的稠合吡啶并[2,3-d]嘧啶衍生物作为有效抗菌剂的有效方法

提出了包含嘧啶部分的化合物的四步制备。该合成特别涉及Vilsmeier-Haack反应，并且对合成的化合物针对革兰氏阳性和革兰氏阴性生物的抗菌活性以及抗真菌活性进行筛选。所有新合成的化合物的结构均通过FTIR，¹ H NMR，质谱和元素分析数据证实。一些新合成的化合物显示出优异的抗微生物活性，并且似乎是该系列中最熟练的成员。