A novel series of benzopyran-3-carboxamide derivatives have been designed and synthesized using a smooth and linear multistep synthesis. Amidation of coumarin-3-carboxylic acid with glycine ethyl ester in the presence of EDC.HCl and HOBt as coupling agent followed by the hydrolysis results in the formation of key synthon, [(2-oxo-2H-1-benzopyran-3-carbonyl) amino] acetic acid 7 which is further coupled with substituted aryl amines using HATU in combination with Hünig’s base to get the target compounds 8(a-h). The synthesized compounds have been screened for their in vitro antibacterial and antioxidant activity and the results are expressed as MIC and IC₅₀ values respectively. Further, the binding ability of synthesized compounds with different proteins have been examined by molecular docking studies.

中文翻译：

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新型2-（苄氨基）-2-氧代乙基] -2-氧代-2H-1-苯并吡喃-3-羧酰胺衍生物的合成，表征及生物学评价

已经设计了一系列新颖的苯并吡喃-3-甲酰胺衍生物，并使用平滑且线性的多步合成方法进行了合成。在EDC.HCl和HOBt作为偶联剂存在下，用甘氨酸乙酯酰胺化香豆素-3-羧酸，然后水解，形成关键的合成子[（2-oxo-2 H -1-benzopyran-3 -羰基）氨基]乙酸7，进一步使用HATU与Hünig碱组合与取代的芳基胺偶联，得到目标化合物8（ah）。筛选了合成的化合物的体外抗菌和抗氧化活性，结果表示为MIC和IC ₅₀值。此外，已经通过分子对接研究检查了合成化合物与不同蛋白质的结合能力。