A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity.

中文翻译：

---

5-（1H-苯并[d]咪唑-2-基）甲基）-3-（3,5-二甲基-4-异恶唑基）-2-芳基噻唑烷-4-酮的合成及其抗炎和镇痛活性

一系列新的5-（1 ħ -苯并[ d ]咪唑-2-基）甲基）-3-（3,5-二甲基-4-异恶唑基）-2-芳基-噻唑烷-4-酮4已经完成通过简单的合成协议。4-苯扎氨基-3,5-二甲基异恶唑3与巯基琥珀酸的反应可提供2-（3-（3,5-二甲基-4-异恶唑基）-4-氧代-2-芳基噻唑烷-5-基）乙酸3，然后用1，2-亚苯基二胺处理将其环化为标题化合物，即异恶唑基噻唑基苯并咪唑4。筛选标题化合物4的抗炎和止痛活性。