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Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones
Indian Journal of Chemistry, Section B Pub Date : 2020-02-12
R Sanjeev, K Thirupathaiah, E Rajanarendar

A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity.

中文翻译:

5-(1H-苯并[d]咪唑-2-基)甲基)-3-(3,5-二甲基-4-异恶唑基)-2-芳基噻唑烷-4-酮的合成及其抗炎和镇痛活性

一系列新的5-(1 ħ -苯并[ d ]咪唑-2-基)甲基)-3-(3,5-二甲基-4-异恶唑基)-2-芳基-噻唑烷-4-酮4已经完成通过简单的合成协议。4-苯扎氨基-3,5-二甲基异恶唑3与巯基琥珀酸的反应可提供2-(3-(3,5-二甲基-4-异恶唑基)-4-氧代-2-芳基噻唑烷-5-基)乙酸3,然后用1,2-亚苯基二胺处理将其环化为标题化合物,异恶唑基噻唑基苯并咪唑4。筛选标题化合物4的抗炎和止痛活性。
更新日期:2020-02-12
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