The present study describes the application of HTIB in the synthesis of several new thiazole derivatives, 4-aryl-2-(2-(1-arylethylidene)hydrazinyl)thiazoles and 2-N-acetylhydrazino-4-arylthiazoles starting from aryl methyl ketones and thiosemicarbazones or N-acetylthiosemicarbazide, respectively. The reaction offers a viable method for the construction of thiazole motif in a single-step without the isolation of the intermediate a-tosyloxy carbonyl compound.

中文翻译：

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HTIB介导使用原位生成的对甲苯氧基酮通过修饰的HTS合成一些新的2,4-二取代的噻唑衍生物

本研究描述了HTIB在合成几种新的噻唑衍生物，4-芳基-2-（2-（1-（芳基亚乙基）肼基）噻唑和2-N-乙酰基肼基-4-芳基噻唑的过程中的应用。分别是thiosemicarbazones或N-acetylthiosemicarbazide。该反应为一步构建噻唑基序提供了一种可行的方法，而无需分离中间体α-甲苯磺酰氧基羰基化合物。