A green, convenient, highly versatile and solvent-free synthetic route for caffeine catalyzed one-pot multi-component synthesis of biologically active 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile has been studied. The green, natural, biodegradable and inexpensive catalyst, eco-safe reaction, solvent-free conditions, avoidance of hazardous or toxic catalysts, simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, the availability and ease of handling of this solid catalyst and good to high yields are the notable benefits for the highly efficient synthesis of these products.

中文翻译：

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咖啡因：一种绿色，天然且可生物降解的催化剂，可在无溶剂条件下方便，便捷地生态安全地合成1H-吡唑并[1,2-b]邻苯并五嗪10,10-二酮衍生物。

一种绿色，方便，高度通用和无溶剂的合成路线，用于咖啡因通过一锅四催化一锅多组分合成具有生物活性的1 H-吡唑并[1,2 - b ]邻苯二甲-5,10-二酮衍生物研究了邻苯二甲酰亚胺，一水合肼，芳基醛和丙二腈的缩合反应。绿色，天然，可生物降解且价格便宜的催化剂，生态安全的反应，无溶剂的条件，避免使用危险或有毒的催化剂，操作和后处理程序简单，无需色谱纯化步骤，可操作性和易用性这种固体催化剂以及良好的高收率是高效合成这些产品的显着优势。