A new series of novel 1-benzoyl-4-(4-aroyl/aroyloxy methyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3f, 3h, 3i, 3n, 3o, 3p have shown good antibacterial activity where as compounds 3b, 3e, 3g, 3i, 3p have displayed better antifungal activity.

中文翻译：

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一锅两步轻松合成新型6,7-二氢-1H-吡唑并[3,4-b]吡啶-5-腈混合物作为抗菌剂

一系列新的新颖的1-苯甲酰基-4-（4-芳酰基/芳酰氧基甲基）-3-甲基-6-氧代-6,7-二氢-1H-吡唑并[3,4- b ]吡啶-5-甲腈从常见的中间体合成，收率很高。已经针对这些化合物针对细菌和真菌的不同致病菌株的抗菌和抗真菌活性进行了筛选。已经确定了测试化合物以及参考标准品的最小抑菌浓度（MBC）和最小杀真菌浓度（MFC）。化合物3c，3f，3h，3i，3n，3o，3p具有良好的抗菌活性3b，3e，3g，3i，3p表现出更好的抗真菌活性。